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Furthermore, the comedy is often necessary to keep spirits high, as the show frequently handles callers who are dealing with serious issues such as drug addiction, sexual abuse, and domestic violence.The show will occasionally answer calls of a general medical nature, especially on slow nights or if they seem peculiar.Drew Pinsky served as executive producer alongside Lisa Gregorisch-Dempsey, who also created the series, and Howard Lapides.

During his first appearance on Carolla's new morning show, Pinsky revealed that the shortlist of candidates included Carson Daly, Joel Mc Hale, Danny Bonaduce, Steve-O and Daniel Tosh.

On July 23, 2006, KROQ-FM disc jockey Stryker was hired as Pinsky's co-host.

Loveline was broadcast live, Sundays through Thursdays at 10pm–midnight PT (Mondays through Fridays at 1am–3am ET). Syndication was usually on rock, alternative, and adult talk radio stations.

Loveline could also be heard online anywhere in the world, by streaming through the websites of affiliate stations.

A practicing physician who is board certified in internal and addiction medicine, he runs his own private practice while also being on staff at Huntington Memorial Hospital, and appearing on countless media.